Effects of menthol cigarette smoking on the disposition kinetics of nicotine
Values in parentheses represent 95% CI.
Total Clearance | Renal CL | Nonrenal CL | T1/2 | VSS | f | CLnic→cot | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | NM | M | NM | M | NM | M | NM | M | NM | M | NM | M | NM | ||||||||
| ml/min | ml/min | ml/min | min | l | ml/min | ||||||||||||||||
| African-Americans | 1290 (1087-1493) | 1472 (1235-1710) | 87 (30-144) | 110 (-1-214) | 1202 (1017-1388) | 1363 (1184-1542) | 147 (97-197) | 145 (76-214) | 214 (167-261) | 236 (172-299) | 0.72c (0.67-0.76) | 0.72c (0.63-0.81) | 922 (773-1071) | 1043 (908-1179) | |||||||
| Whites | 1288 (853-1724) | 1390 (878-1902) | 87 (30-143) | 76 (29-121) | 1202 (782-1622) | 1315 (831-1799) | 166 (120-210) | 136 (81-191) | 231 (165-297) | 202 (154-250) | 0.60c (0.49-0.70) | 0.59c (0.54-0.64) | 778 (463-1092) | 837 (477-1197) | |||||||
| All | 1289a (1085-1493) | 1431 (1191-1672) | 87 (52-121) | 92 (40-144) | 1202a (1008-1397) | 1339 (1191-1672) | 156 (127-185) | 140 (103-178) | 223 (188-258) | 219 (184-254) | 0.66 (0.60-0.72) | 0.65 (0.39-0.71) | 850b (696-1004) | 940 (766-1115) | |||||||