TABLE 2

Acute toxicity of several spin probes Administrations were bolus i.v. injection. Numbers in parentheses are number of mice affected/used.


Probes

Dose

Result
μmol/g
TEMPO 0.50 A mouse died within 3 min after injection.
0.25 Mice (4/4) survived until sacrificed (20 min after injection).
TEMPOL 2.00 A mouse died within 3 min after injection.
1.50 Mice (4/4) survived until sacrificed (20 min after injection).
TEMPONE 1.50 Mice (2/2) died within 16 min after injection.
1.00 Mice (4/4) survived until sacrificed (30 min after injection).
Amino-TEMPO 1.00 Mice (2/2) died within 3 min after injection.
0.75 Mice (2/2) died within 3 min after injection.
0.50 Mice (4/4) survived until sacrificed (20 min after injection).
CAT-1 1.00 Mice (2/2) died immediately after injection.
0.75 Mice (2/2) died immediately after injection.

0.50
Mice (4/4) survived until sacrificed (30 min after injection).