TABLE 3

Comparison of GPFX clearance, plasma protein binding, and portal vein blood flow rate among mdr1a(–/–), mdr1a/1b(–/–), and mdr1a/1b(+/+)

CLtot,pa
CLbile,pb
CLurine,pb
CLmet,pc
CLother,pd
Blood Flow Rate
Plasma Protein Bindinge
 0.2 μg/ml
2 μg/ml
ml/min/kg ml/min/kg ml/min/kg ml/min/kg ml/min/kg ml/min/kg %
mdr1a/1b(+/+) 49.5 ± 1.1 5.81 ± 1.07 8.92 ± 0.76 26.3 ± 1.0 8.47 ± 1.95 38.8 ± 3.5 34.7 ± 2.5 39.9 ± 0.3
mdr1a(-/-) 34.2 ± 2.3* 5.22 ± 0.68 5.39 ± 0.30* 20.8 ± 3.2 2.86 ± 4.00 33.1 ± 3.5 34.7 ± 3.8 39.1 ± 0.6
mdr1a/1b(-/-)
39.2 ± 1.8*
6.59 ± 0.49
6.47 ± 0.89
23.3 ± 1.4
2.81 ± 2.44
29.2 ± 2.7*
36.8 ± 3.3
34.8 ± 0.2*

  • Each value represents the mean ± S.E. of 3 to 4 mice.

  • ↵ a Total clearance.

  • ↵ b Biliary and urinary clearance.

  • ↵ c Metabolic clearance.

  • ↵ d Nonhepatic and nonrenal clearance.

  • ↵ e Each value represents the mean ± S.E. of three samples.

  • ↵* P < 0.05 significantly different from mdr1a/1b(+/+).