TABLE 5

In vitro IC50 values for the inhibition of human P450 enzymes by GF120918A

Data provided as mean ± S.D.


Enzyme

IC50
μM
CYP1A2 22.4 ± 1.7
CYP2C9 18.5 ± 2.1
CYP2C19 38.5 ± 4.4
CYP2D6 49.9 ± 17.5
CYP3A4
10.5 ± 0.4