TABLE 4

Estimated plasma protein binding and recovery from the equilibrium dialysis device for GF120918A

Data provided as mean ± S.D. where possible.


Incubation

Estimated Plasma Protein Binding

Recovery from Donor Side of Equilibrium Device
%
Mouse >98.5 18.1 ± 16.5
Rat 99.0 ± 0.6 53.9 ± 18.1
Dog 99.8 ± 0.1 52.2 ± 7.8
Monkey 99.9 ± 0.01 78.2 ± 5.7
Human
>99.9
82.5 ± 9.7