TABLE 2

Systemic pharmacokinetic parameters of GF120918A after oral administration in nonrodents

Data provided as mean ± S.D. except Tmax, which is median (range).




Cmax

Tmax

AUC

DNAUC
ng/ml min min · μg/ml min · kg/l
Dog
3 mg/kg solution 117 ± 34 360 (180-360) 79.4 ± 33 26.6 ± 10.8
3 mg/kg suspension 125 ± 30 360 (180-480) 97.0 ± 40.5 32.7 ± 13.6
30 mg/kg suspension 219 ± 50 360 (242-480) 202 ± 78 7.19 ± 2.77
Monkey
3 mg/kg solution 105 ± 43 360 (240-490) 62.3 ± 9.3 19.6 ± 2.9
3 mg/kg suspension 85.5 ± 37.0 240 (240-240) 40.4 ± 11.1 13.3 ± 3.6
30 mg/kg suspension
179 ± 100
361 (240-600)
187 ± 72
6.30 ± 2.44