Systemic pharmacokinetic parameters of GF120918A after oral administration in rodents
Data provided as mean ± S.D. except Tmax, which is median (range).
Cmax | Tmax | AUC | DNAUC | |
|---|---|---|---|---|
| ng/ml | min | min · μg/ml | min · kg/l | |
| Mouse | ||||
| 3 mg/kg solution | 64.1 ± 7.9 | 120 (120-240) | 19.9 ± 1.3 | 6.34 ± 0.37 |
| 3 mg/kg suspension | 86.0 ± 24.7 | 120 (120-240) | 26.7 ± 4.2 | 7.99 ± 1.74 |
| 30 mg/kg suspension | 586 ± 25 | 240 (120-240) | 319 ± 81 | 11.3 ± 2.8 |
| 300 mg/kg suspension | 962 ± 81 | 489 (240-1460) | 1151 ± 77 | 3.84 ± 0.26 |
| Rat | ||||
| 3 mg/kg PEG solution | 15.1 ± 3.6 | 490 (360-603) | 6.37 ± 1.54 | 2.07 ± 0.51 |
| 3 mg/kg Cavitron solution | 42.7 ± 6.6 | 240 (240-360) | 28.6 ± 5.1 | 8.70 ± 1.20 |
| 3 mg/kg suspension | 18.0 ± 3.8 | 240 (240-240) | 6.65 ± 1.52 | 2.20 ± 0.48 |
| 30 mg/kg suspension | 133 ± 29 | 360 (360-480) | 99.9 ± 28.1 | 3.31 ± 0.94 |
| 300 mg/kg suspension | 98.9 ± 51.0 | 480 (360-480) | 107 ± 46 | 0.364 ± 0.148 |