Effects of isoflurane on Na+ channel gating All channels are coexpressed with β1 subunits. Values are shown as mean ± S.E.M.
Activation | Inactivation | |||||
|---|---|---|---|---|---|---|
| Control V1/2 | Isoflurane V1/2 | Control V1/2 | Isoflurane V1/2 | |||
| mV | ||||||
| Nav1.2 | -32.7 ± 5.4 | -32.4 ± 6.5 | -58.7 ± 3.8 | -67.6 ± 3.0* | ||
| Nav1.4 | -37.4 ± 3.0 | -38.0 ± 2.3 | -56.3 ± 3.3 | -64.3 ± 4.7* | ||
| Nav1.6 | -33.8 ± 3.9 | -32.2 ± 4.0 | -60.1 ± 2.5 | -68.8 ± 2.8* | ||
| Nav1.8 | -3.2 ± 3.0 | -3.9 ± 1.9 | -35.3 ± 4.8 | -36.1 ± 3.9 | ||
↵* P < 0.05, compared with control using paired t test