Blockade by D2 and/or D3 receptor antagonists (pKB values) of S32504-induced Gαi3 activation and MAP kinase phosphorylation at hD3 and hD2L receptors Data (pKB values for antagonist properties) are means ± S.E.M. of three determinations, each performed in triplicate.
hD3 | hD2L | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| pKia | Gαi3 | MAP Kinase | pKi | Gαi3 | MAP Kinase | |||||
| Haloperidol | 8.54 | 8.68 ± 0.03 | 9.83 ± 0.07 | 9.39 | 9.44 ± 0.09 | 9.48 ± 0.14 | ||||
| S33084 | 9.58 | 9.44 ± 0.10 | 9.27 ± 0.20 | 7.53 | 7.70 ± 0.03 | NT | ||||
| L741.626 | 7.27 | 7.66 ± 0.10 | NT | 8.53 | 8.42 ± 0.07 | 8.61 ± 0.08 | ||||