TABLE 4

Affinities of S32504 at multiple classes of 5-HT receptor and α-adrenoceptor Data are means ± S.E.M. of two to four determinations, each performed in triplicate. For additional, procedural details, see Millan et al. (2002).

Receptor	Tissue	Radioligand (nM)	S32504	Ropinirole
hD₃	CHO cells	[¹²⁵I]Iodosulpride (0.2)	8.05	7.43^a
h5-HT_1A	CHO cells	[³H]8-OH-DPAT (0.4)	6.59 ± 0.07	6.54^a
h5-HT_1B	CHO cells	[³H]GR125,743 (1.0)	<5	<5^a
h5-HT_1D	CHO cells	[³H]GR125,743 (1.0)	6.58 ± 0.08	5.86^a
h5-HT_2A	CHO cells	[³H]Ketanserin (0.5)	5.28 ± 0.01	<5^a
h5-HT_2B	CHO cells	[³H]Mesulergine (1.0)	5.34 ± 0.08	5.42^a
h5-HT_2C	CHO cells	[³H]Mesulergine (1.0)	<5	<5^a
5-HT₃	N1E-115 mouse cells	[³H]BRL43694 (1.0)	<5	<5
5-HT₄	Guinea pig striatum	[³H]GR113808 (0.1)	<5	<5
h5-HT_5A	CHO cells	[³H]LSD (1)	<5	<5
h5-HT₆	CHO cells	[³H]LSD (2)	<5	<5
h5-HT₇	HEK-293	[³H]LSD (1)	6.18 ± 0.06	5.82 ± 0.10
rα₁	Rat cortex	[³H]Prazosin (0.2)	<5	<5
hα_1A	CHO cells	[³H]Prazosin (0.1)	<5	<5^a
hα_1B	CHO cells	[³H]Prazosin (0.1)	<5	<5^a
hα_1D	CHO cells	[³H]Prazosin (0.1)	<5	<5^a
rα_2D	Rat cortex	[³H]RX821,002 (0.4)	<5	5.35^a
hα_2A	CHO cells	[³H]RX821,002 (0.7)	5.09 ± 0.05	5.73^a
hα_2B	CHO cells	[³H]RX821,002 (0.4)	5.78 ± 0.14	6.12^a
hα_2C	CHO cells	[³H]RX821,002 (0.6)	<5	5.92^a

h, human; r, rat.
↵ a From Millan et al. (2002)