Binding affinities (Ki) MPPA-4F and PNU-109291 at h5-HT receptors
Data are the mean ± standard error from three to five independent experiments.
5-HT Receptor Subtype | Affinity (Ki) | ||
|---|---|---|---|
| MPPA-4F | PNU-109291 | ||
| nM | |||
| 1A | 356.9 ± 32.9 | 1511.9 ± 71.6 | |
| 1B | 4.6 ± 0.6 | >10,000 | |
| 1D | 62 ± 10.8 | 2.5 ± 0.07 | |
| 1E | 2795 ± 420.8 | >10,000 | |
| 1F | 1595 ± 260.8 | >10,000 | |
| 2A | 1546 ± 113.4 | 1,676.13 ± 108.6 | |
| 2B | 3148 ± 1133.8 | >10,000 | |
| 2C | 995 ± 132 | >10,000 | |
| 4 | 2960 ± 660.4 | N.D. | |
| 6 | 3267.8 ± 319.6 | >10,000 | |
| 7 | >5000 | >10,000 | |
N.D., not determined.