TABLE 1

Summary of reported inductive response in Fa2N-4 cells compared with response of primary human hepatocytes


Parameter

Inducer

Fa2N-4 Cellsa

Primary Cellsb
-fold increase
CYP1A2 β-Naphthoflavone 15 13
CYP2C9 Rifampin 3.8 3.5
Phenobarbital 2.6 1.8
CYP3A4 Rifampin 17 10

Phenobarbital
9.3
3.3
  • a Fa2N-4 mRNA data reported as-fold increase over vehicle-treated controls (this study).

  • b From Madan et al. (2003). Multiple donors of primary human hepatocytes were used. Concentrations were 33 μM β-naphthoflavone, 10 or 50 μM rifampin, and 250 μM phenobarbital. Enzyme activity data reported as -fold increase over vehicle-treated controls.