Summary of reported inductive response in Fa2N-4 cells compared with response of primary human hepatocytes
Parameter | Inducer | Fa2N-4 Cellsa | Primary Cellsb | |
---|---|---|---|---|
-fold increase | ||||
CYP1A2 | β-Naphthoflavone | 15 | 13 | |
CYP2C9 | Rifampin | 3.8 | 3.5 | |
Phenobarbital | 2.6 | 1.8 | ||
CYP3A4 | Rifampin | 17 | 10 | |
| Phenobarbital | 9.3 | 3.3 |
↵ a Fa2N-4 mRNA data reported as-fold increase over vehicle-treated controls (this study).
↵ b From Madan et al. (2003). Multiple donors of primary human hepatocytes were used. Concentrations were 33 μM β-naphthoflavone, 10 or 50 μM rifampin, and 250 μM phenobarbital. Enzyme activity data reported as -fold increase over vehicle-treated controls.