TABLE 2

The Ki values of various NSAIDs for rOat1, rOat3, and RFC-1 Inhibitory effect of various NSAIDs on the uptake of PAH, PCG, and MTX by rOat1, rOat3, and RFC-1-transfected cells, respectively, were examined. The Ki values were determined by nonlinear regression analysis. Data were taken from Fig. 7. All values represent the mean ± S.D.


NSAID

rOat1

rOat3

RFC-1
μM μM μM
Salicylate 2110 ± 190 519 ± 132 2930 ± 660
Diclofenac 4.56 ± 1.24 3.17 ± 0.43 69.6 ± 28.9
Sulindac 99.9 ± 18.6 7.72 ± 1.32 N.D.
Indomethacin 7.44 ± 3.88 1.29 ± 0.46 106 ± 31
Etodolac >100 9.98 ± 1.48 N.D.
Tolmetin 15.4 ± 3.2 8.78 ± 2.32 N.D.
Ibuprofen 4.33 ± 0.40 3.57 ± 1.09 215 ± 75
Ketoprofen 6.11 ± 1.66 4.31 ± 1.28 310 ± 123
Naproxen 5.54 ± 0.89 19.1 ± 6.9 97.2 ± 43.8
Phenylbutazone 47.9 ± 9.2 8.48 ± 0.78 285 ± 65
Piroxicam
N.D.
4.19 ± 0.70
N.D.
  • N.D., not determined.