Pharmacological parameters for 5-HT receptor agonist-induced contraction in endothelium-denuded rat renal artery Values are means ± S.E.M. for the number of animals in parentheses.
Agonist (n = 4-7) | -log EC50 [M] | Percentage of Maximum PE Contraction |
|---|---|---|
| DOI | 8.21 ± 0.09 | 124.7 ± 8.7 |
| 5-HT | 7.03 ± 0.02 | 124.8 ± 9.5 |
| 5-Methoxytryptamine | 6.96 ± 0.03 | 146.8 ± 12.4 |
| mCPP | 6.65 ± 0.04 | 68.7 ± 4.9 |
| α-Methyl-5-HT | 6.64 ± 0.05 | 141.8 ± 8.4 |
| BW723C86 | 6.50 ± 0.09 | 58.8 ± 12.1 |
| (+)Norfenfluramine | 6.41 ± 0.05 | 138.7 ± 13.4 |
| 2-Methyl-5-HT | 6.03 ± 0.08 | 165.8 ± 27.0 |
| CP93129 | 5.51 ± 0.07 | 38.1 ± 7.6 |
| 5-CT | 5.49 ± 0.03 | 107.1 ± 6.1 |
| (±)8-OH-DPAT | 5.20 ± 0.13 | 49.8 ± 13.0 |
| Sumatriptan | 4.14 ± 0.09 | 15.3 ± 7.8 |
| LY344864 | —a | 0 ± 0 |
PE, phenylephrine (10 μM).
↵ a Could not be obtained