Single-dose pharmacokinetic parameters of bosentan in mdr-1a knockout and wild-type (FVB) mice
Oral | AUC0-inf. | Cmax | Tmax | F |
|---|---|---|---|---|
| ng · h/ml | ng/ml | h | % | |
| mdr-1a knockout | 1190 | 432 | 1.0 | 74 |
| Wild-type (FVB) | 953 | 299 | 2.0 | 53 |
| Intravenous | AUC0-inf. | CL | Vss | T1/2 |
|---|---|---|---|---|
| ng · h/ml | ml/min · kg | l/kg | h | |
| mdr-1a knockout | 807 | 53 | 2.5 | 0.8 |
| Wild-type (FVB) | 893 | 47 | 2.1 | 0.8 |