TABLE 1

Comparison of parameters between control livers perfused with digoxin only and livers co-perfused with rifampicin or quinidine


Parametera

Treatment Group
Control
Quinidine
Rifampicin
Digoxin AUCb (nM·min) 3880 ± 210 3220 ± 340* 5200 ± 240**
Dg2 AUCb (nM·min) 1480 ± 90 1690 ± 120* 1130 ± 200*
Dg2 AUC/digoxin AUC 0.382 ± 0.029 0.530 ± 0.076** 0.217 ± 0.037*
Dg2/digoxin in liverc 0.131 ± 0.023 0.488 ± 0.192** 0.136 ± 0.045
Liver/perfusate (inhibitor)d
N/A
8.08 ± 0.72
13.3 ± 3.0
  • N/A, not applicable.

  • a Mean ± S.D., n = 6 per group.

  • b AUC calculated using the linear trapezoidal method up to 60 min.

  • c Ratio of amount of Dg2 formed to amount of digoxin retained in liver at 60 min.

  • d Ratio of concentrations of quinidine or rifampicin in liver to perfusate at 60 min.

  • * Significantly different from control, p < 0.05.

  • ** Significantly different from control, p < 0.01.