Effect of 10-day repeated quinpirole treatment on maximum efficacy and EC50 of dopamine-stimulated [35S]GTPγS binding in the NAc
Quinpirole Dose (mg/kg) | |||||
|---|---|---|---|---|---|
| 0 | 0.05 | 0.1 | |||
| NAc core | |||||
| Maximal efficacy (±S.E.M.) | 67.0 ± 5.8% | 61.8 ± 6.9% | 54.0 ± 5.4% | ||
| EC50 (95% confidence interval) | 35.6 μM (13, 98) | 31.2 μM (9, 105) | 40.4 μM (11, 146) | ||
| NAc shell | |||||
| Maximal efficacy (±S.E.M.) | 51.8 ± 5.9% | 55.7 ± 6.9% | 46.0 ± 6.4% | ||
| EC50 (95% confidence interval) | 51.5 μM (16, 169) | 73.0 μM (21, 259) | 29.3 μM (6, 149) | ||