TABLE 1

Hemodynamic effects of saline and graded doses of ivabradine Values are mean ± S.E.M. n = 7.

Drug
Baseline
Rest
Rest Paced
Exercise
Exercise Paced
Heart rate (beats/min) Saline 111 ± 3 111 ± 3 125 ± 0 221 ± 5 249 ± 1
Ivabradine 0.25 mg/kg 110 ± 7 104 ± 6 125 ± 0 183 ± 5* 250 ± 1
Ivabradine 0.5 mg/kg 107 ± 5 93 ± 5* 125 ± 0 175 ± 4* 249 ± 0
Ivabradine 1 mg/kg 107 ± 4 88 ± 3* 125 ± 0 150 ± 5* 250 ± 1
Left ventricular systolic pressure (mm Hg) Saline 136 ± 5 136 ± 5 135 ± 6 174 ± 10 169 ± 10
Ivabradine 0.25 mg/kg 138 ± 8 143 ± 8 142 ± 8 183 ± 11 180 ± 11
Ivabradine 0.5 mg/kg 135 ± 9 134 ± 8 137 ± 10 173 ± 13 167 ± 14
Ivabradine 1 mg/kg 134 ± 7 137 ± 8 141 ± 10 178 ± 11 173 ± 12
Left ventricular end-diastolic pressure (mm Hg) Saline 7 ± 1 7 ± 1 5 ± 1 16 ± 3 9 ± 3
Ivabradine 0.25 mg/kg 7 ± 1 10 ± 1 6 ± 1 22 ± 2* 11 ± 3
Ivabradine 0.5 mg/kg 8 ± 1 10 ± 1 5 ± 1 24 ± 2* 11 ± 2
Ivabradine 1 mg/kg 7 ± 1 13 ± 2 8 ± 2 27 ± 2* 10 ± 2
LV dP/dtmax (mm Hg/s) Saline 3516 ± 270 3516 ± 270 3502 ± 305 7164 ± 920 7395 ± 772
Ivabradine 0.25 mg/kg 3626 ± 315 3691 ± 300 3761 ± 343 7278 ± 929 7909 ± 996
Ivabradine 0.5 mg/kg 3310 ± 294 3398 ± 338 3379 ± 348 6971 ± 911 7597 ± 1163
Ivabradine 1 mg/kg 3292 ± 219 3419 ± 302 3347 ± 287 6405 ± 682 7474 ± 1098
Left ventricular end-diastolic wall stress (g/cm2) Saline 25 ± 2 26 ± 2 23 ± 3 64 ± 12 37 ± 8
Ivabradine 0.25 mg/kg 24 ± 3 34 ± 5 25 ± 4 79 ± 16 42 ± 11
Ivabradine 0.5 mg/kg 29 ± 3 37 ± 3* 21 ± 5 87 ± 14* 40 ± 10
Ivabradine 1 mg/kg 26 ± 1 49 ± 8* 26 ± 9 103 ± 15* 40 ± 8
Left ventricular mean ejection wall stress (g/cm2) Saline 350 ± 30 350 ± 30 352 ± 33 432 ± 43 420 ± 51
Ivabradine 0.25 mg/kg 359 ± 34 374 ± 38 370 ± 32 442 ± 40 420 ± 36
Ivabradine 0.5 mg/kg 356 ± 34 370 ± 29 357 ± 32 448 ± 35 414 ± 31
Ivabradine 1 mg/kg
357 ± 27
382 ± 37
387 ± 35
450 ± 35
403 ± 31

  • ↵* p < 0.05 vs. saline; LV dP/dtmax, maximal value of the first derivative of left ventricular pressure over time