TABLE 2

Bidirectional Papp of BZT analogs and cocaine (1 × 10−4 M) and Papp of BZT analogs with PSC833 across BBMEC monolayers

Papp listed as 10−4 cm/s. Data listed as mean ± S.D. at n = 3. Papp sucrose = 1 × 10−5 cm/s, Papp propranolol = 15 × 10−5 cm/s, transepithelial electrical resistance = 100 to 150 Ω · cm2.


Compound

A → B

B → Aa

B → A/A → B

A → B with PSC833b
Cocaine 1.63 ± 0.05 6.88 ± 0.20 4.2 2.12 ± 0.07
AHN 2-003 1.54 ± 0.10 8.51 ± 0.90 5.5 1.84 ± 0.13
AHN 1-055 2.15 ± 0.10* 11.5 ± 1.40 5.3 3.10 ± 0.10
AHN 2-005 1.56 ± 0.03 9.86 ± 1.08 6.2 2.91 ± 0.15
JHW 007
2.83 ± 0.10*
22.8 ± 2.00**
8.0
3.87 ± 0.02
  • * Significant difference (p < 0.05) for A → B.

  • ** Significant difference (p < 0.05) for B → A.

  • a Significant difference (p < 0.05) for B → A versus A → B for all compounds.

  • b Significant difference (p < 0.05) for A → B versus A → B with PSC833.