TABLE 1

Structural substituents, physicochemical properties, DAT binding, and DA uptake inhibition data on BZT analogs and cocaine (Agoston et al., 1997)

Compound	R	Mol. Wt.	cLogP^a	[³H]WINBinding^b (K_I)	Dopamine Uptake^c (IC₅₀)
				nM
AHN 2-003	H	365.85	3.10	11	9.7
AHN 1-055	CH₃	393.16	3.95	12	71
AHN 2-005	CH₂CH=CH₂	405.92	4.52	30	14
JHW 007	(CH₂)₃CH₃	421.96	5.53	25	370
Cocaine		303.31	2.72	300-400	150-200

↵ a Calculated log of the partition coefficient (cLogP).
↵ b Affinity for the DAT by determination of the displacement of [³H]WIN 35,428, an analog of cocaine.
↵ c Inhibition of [³H]DA uptake.