TABLE 3

Dose-related antinociception produced by the oral administration of ketoprofen or the combination of Glu plus ketoprofen (Keto) (weight ratio 2.63:1) to mice

Antinociception was measured 30 min after dosing and is expressed as the ratio (number of nonresponders)/(number in group). The ED50 (±95% confidence interval) was determined from probit regression analysis.


Treatment

Antinociception

ED50
mg/kg p.o.
Ketoprofen (alone)
30 2/10
60 4/10
120 6/10 94.8 ± 30.0
240 7/10
Glu/Keto (2.63:1)
62.5/23.8 5/10
93.2/35.6 6/10 24.2 ± 11.7*
125/47.5
7/10

  • * Significantly different from ketoprofen alone (p < 0.01, ANOVA).