TABLE 2

Antinociceptive effect produced by a fixed quantity (26.1 mg/kg p.o.) of Ibu plus each of six different amounts of Glu to mice

Antinociception was measured 30 min after dosing and is expressed according to antinociception = (number of nonresponders)/(number in group).


Group

Glu

Ibu

Ratio

Antinociception


Expected Actual
A 13.1 26.1 0.5:1 5/10 5/10 }10/20
B 26.1 26.1 1:1 5/10 5/10
C 52.2 26.1 2:1 5/10 8/10 }43/50*
D 131 26.1 5:1 5/10 9/10
E 250 27.8 9:1 10/20 17/20
F
500
26.1
19:1
5/10
9/10
  • * Significantly different from A and B combined (p < 0.01,ψ2 with Yates correction).