TABLE 1

Age category definitions for fetal and pediatric liver microsome samples

The divisions were determined by regression tree analysis of the CYP3A5 protein levels as described under Materials and Methods and only considering liver microsome samples with detectable levels of CYP3A5 protein. Age range is defined as gestational age for fetal samples or the total of postnatal age and 280 days (estimated gestational age). A total of 212 individual samples were analyzed for immunodetectable CYP3A5 levels.


Age Range (Days)

Approximate Description

N

n = African-American

Node Deviance
Age <144 1st/early 2nd trimester 12 8 151.1
144 < Age <221 Late 2nd trimester 16 7 483.2
221 < Age <298 Late 2nd trimester to infancy 16 8 395.7
298 < Age <341 1 to 2 months 13 5 272.1
341 < Age <430 3 to 5 months 20 10 269.1
430 < Age <981 5 months to 2 years 10 7 416.3
981 < Age <3,668 2 to 9 years 16 10 280.5
3668 < Age
>9 years
12
4
41.64