TABLE 1

Changes in arterial blood pressure and heart rate following injections of CVT-3146 and adenosine in conscious dogs

MAP (mm Hg)
HR (beats/min)
Baseline
Response
Baseline
Response
CVT-3146 (μg/kg)
    0.10 103 ± 4 100 ± 4*,† 90 ± 3 98 ± 4*
    0.25 102 ± 4 97 ± 4*,† 88 ± 3 100 ± 4*,†
    0.50 102 ± 4 95 ± 5*,† 87 ± 3 111 ± 7*
    1.00 102 ± 4 95 ± 5*,† 88 ± 3 123 ± 7*
    2.50 103 ± 3 89 ± 4*,† 87 ± 3 139 ± 8*
Adenosine (μg/kg)
    10 104 ± 3 96 ± 4* 89 ± 3 103 ± 4*
    25 102 ± 3 92 ± 4* 87 ± 3 113 ± 7*
    50 103 ± 4 86 ± 4* 86 ± 3 121 ± 9*
    100 104 ± 4 84 ± 4* 89 ± 3 140 ± 9*
    250
105 ± 3
75 ± 5*
89 ± 3
152 ± 10*

  • Mean ± S.E.M., n = 13; * P < 0.05, compared with the baseline; †P < 0.05, compared with the response to adenosine.