TABLE 2

Allelic frequency and prevalence of UGT1A9 alleles



n

Allele Frequency

Genotype Frequency (%)a

*1
*2
*3
*1/*1
*1/*2
*1/*3
Amino acid change Cys3 Met33 Tyr3 Met33 Cys3Thr33
Functional change “Wild type” Similar activity for SN-38 and flavopiridol Decreased activity for SN-38; similar activity for flavopiridol
Population characteristics
    Caucasian (French Canadian) 201 0.978 0.000 0.022 95 0 4.4
    Caucasian (American) 100 0.964 0.000 0.036 97 0 3.0
    African (American)
20
0.975
0.025
0.000
95
5
0
  • a Subjects homozygous for variant UGT1A9 alleles were not observed in the population tested.