TABLE 2

Cellular activity of SU10944

Receptor (Cell Type)
IC50
μM
SCFRa (MO7e) 1.6 ± 0.3
(n = 2)
PDGFRβb (3T3) 30.6 ± 13.3
(n = 6)
EGFRb (3T3) >50
(n = 3)
FGFR-1b (3T3) >50
(n = 3)

  • ↵ a Functional activity of SCFR was measured in a survival assay for MO7e cells.

  • ↵b Functional activity was measured by BrdU incorporation in 3T3 cells stably transfected with the receptor.