TABLE 2

Mean steady-state digoxin pharmacokinetic parameter values before and during coadministration of 750 mg of avasimibe

Twelve subjects received 0.25 mg of digoxin tablets daily from days 1 through 20, and 750 mg avasimibe daily on days 10 through 20. Plasma samples were collected on days 10 and 20 for determination of digoxin concentrations as described under Materials and Methods.


Parameter

Least-Squares Mean Values


Digoxin
Digoxin with Avasimibe
Ratio
90% Confidence Interval
n 11 10
Cmax, ng/ml 1.52 1.10 72.8 65.8-80.5
Tmax, h 1.27 1.32 104 Not applicable
AUC(0-24) ng · h/ml 14.5 9.22 63.5 58.3-69.2
Cmin, ng/ml 0.50 0.27 55.1 43.3-70.2
CL/F, ml/min 324 490 151 130-173
Ae% 45.6 33.0 70.8 62.4-79.1
CLr, ml/min
137
150
110
101-119
  • Ratio, ratio of treatment mean values expressed as a percentage (100% · test/reference); 90% confidence interval, 90% confidence interval estimate for the ratio (test/reference) of treatment mean values, expressed as a percentage of the reference mean.