Mean steady-state digoxin pharmacokinetic parameter values before and during coadministration of 750 mg of avasimibe
Twelve subjects received 0.25 mg of digoxin tablets daily from days 1 through 20, and 750 mg avasimibe daily on days 10 through 20. Plasma samples were collected on days 10 and 20 for determination of digoxin concentrations as described under Materials and Methods.
Parameter | Least-Squares Mean Values | ||||
|---|---|---|---|---|---|
|
Digoxin
|
Digoxin with Avasimibe
|
Ratio
|
90% Confidence Interval
| ||
| n | 11 | 10 | |||
| Cmax, ng/ml | 1.52 | 1.10 | 72.8 | 65.8-80.5 | |
| Tmax, h | 1.27 | 1.32 | 104 | Not applicable | |
| AUC(0-24) ng · h/ml | 14.5 | 9.22 | 63.5 | 58.3-69.2 | |
| Cmin, ng/ml | 0.50 | 0.27 | 55.1 | 43.3-70.2 | |
| CL/F, ml/min | 324 | 490 | 151 | 130-173 | |
| Ae% | 45.6 | 33.0 | 70.8 | 62.4-79.1 | |
|
CLr, ml/min
|
137
|
150
|
110
|
101-119
| |
Ratio, ratio of treatment mean values expressed as a percentage (100% · test/reference); 90% confidence interval, 90% confidence interval estimate for the ratio (test/reference) of treatment mean values, expressed as a percentage of the reference mean.