Numbers (percentage) of mice developing PPE-like lesions as a function of dose schedule
Values represent the number of mice with PPE-like lesions at the time of receiving the stated dose. For each dose schedule, mice were injected i.v. with SL-DXR at a DXR dose of 9 mg/kg.
Dose Schedule | Dose 2 | Dose 3 | Dose 4 |
|---|---|---|---|
| q1 week | 0/75 (0%) | 8/50 (16%) | 17/24 (70%) |
| q2 weeks | 5/75 (7%) | 5/50 (10%) | 8/25 (32%) |
|
q4 weeks
|
3/90 (3%)
|
3/60 (5%)
|
0/30 (0%)
|