TABLE 2

Acyclovir pharmacokinetic parameters following oral administration of 500 mg valacyclovir to humans (n = 10)


Subject

Cmax

AUC0—last

AUC0—inf
μg/ml μg · h/ml
5100 1.79 6.98 7.33
5102 2.37 8.62 9.12
5104 2.31 8.95 9.70
5106 2.80 7.13 7.68
5107 3.68 12.00 12.20
5108 3.86 11.70 12.10
5109 a a a
5110 2.37 9.15 9.96
5111 3.17 8.72 9.98
5112 1.72 10.00 10.40
5115 3.47 11.10 12.40
Mean 2.75 9.44 10.09
% CV
28.00
19.00
18.00
  • a Subject did not participate in this Phase.