Compound B (J-113397) |
|
|
|
i.t., i.c.v. | Rat formalin test | Pronociceptive in phase II | Yamamoto et al. (2001) |
Systemic, i.p. | No effect | ||
Local peripheral | Capsaicin-induced thermal nociception in monkeys | No effect on its own | Ko et al. (2002a) |
Systemic, s.c.t. | Mouse tail-flick test | No effect | Ozaki et al. (2000) |
Systemic, s.c.t. | Mouse tail-flick test and tail pinch | Attenuation of tolerance to morphine | Ueda et al. (2000) |
JTC-801 | |||
i.t. | Mouse formalin test | Antinociceptive | Muratani et al. (2002) |
Systemic, i.v./p.o. | Rat formalin test | Antinociceptive (naloxone insensitive) | Yamada et al. (2002) |
Systemic, p.o. | Mouse hot plate and rat formalin test | Antinociceptive (naloxone insensitive) | Shinkai et al. (2000) |
[Nphe1]N/OFQ(1-13)NH2 | |||
i.c.v. | Mouse tail withdrawal test | Antinociceptive (naloxone insensitive) | Caló et al. (2000) |
i.t. | Rat chronic constriction injury | No effect | Corradini et al. (2001) |
i.t. | Flexor reflex in spinalized rats | Facilatory (pronociceptive) | Xu et al. (2002) |
i.c.v. | Mouse tail withdrawal test | Potentiation of morphine antinociception and attenuation of tolerance to morphine | Rizzi et al. (2000) |
i.c.v. | Mouse tail-flick test and hot plate | Antinociceptive (ineffective in NOP-/- mice), no tolerance development | Di Giannuario et al. (2001) |
UFP-101 | |||
i.c.v. | Tail withdrawal test | Antinociceptive | Calò et al. (2002) |