TABLE 1

Effect of vascular perfusion on the apparent permeability of tacrolimus in rats

Values are expressed as the mean ± S.D. of four experiments.

Intestinal Site
Apparent Permeabilitya
Without Vascular Perfusion
With Vascular Perfusion
10-4 cm/s
Jejunum 0.352 ± 0.048 0.324 ± 0.029
Ileum
0.166 ± 0.048
0.174 ± 0.011

  • ↵ a Calculated based on the total tacrolimus concentration in the luminal perfusion solution (25 μg/ml).