Percentage of the dose recovered as CDF at the end of the 2-h perfusion
| Group | Bile | Perfusate | Total |
|---|---|---|---|
| Wild-type rats | |||
| CDFDA control | 65 ± 8 | 10 ± 3 | 75 ± 9 |
| CDFDA without taurocholate | 65 ± 1 | 10 ± 3 | 75 ± 3 |
| CDFDA + probenecid (260 μM) | 15 ± 21-150 | 48 ± 31-150 | 63 ± 1 |
| CDF | 80 ± 51-150 | 11 ± 7 | 91 ± 31-150 |
| TR− rats | |||
| CDFDA control | 0.05 ± 0.02 | 63 ± 2 | 63 ± 2 |
| CDFDA + probenecid (260 μM) | 0.04 ± 0.01 | 54 ± 7 | 54 ± 7 |
| CDFDA + probenecid (4 mM) | 0.04 ± 0.01 | 44 ± 51-150 | 44 ± 51-150 |
Data are expressed as percentage of CDF or CDFDA dose recovered as CDF at the end of the 2-h perfusion in isolated perfused livers from wild-type and TR− rats. Values are mean ± S.D.,n = 3/group.
↵1-150 p < 0.05, values compared with control in relevant rat strain.