Summary of kinetic parameters of DAT in the nucleus accumbens of the rat after 10 days of pretreatment with saline or cocaine and a subsequent 10-day withdrawal period.
| Saline | Cocaine | |
|---|---|---|
| k(days−1) | 0.32 | 0.31 |
| r (fmol/mg tissue/day) | 93 | 91 |
| t 1/2(days) | 2.2 | 2.2 |
In this table, k is the transporter degradation rate constant, r is the transporter production rate, andt1/2 is the half-life of transporter repopulation. These values were calculated by generating a linear fit of the data shown in Fig. 4.