Table 1

Summary of kinetic parameters of DAT in the striatum of the rat after 10 days of pretreatment with saline or cocaine and a subsequent 10-day withdrawal period

k (days−1)0.330.74
r (fmol/mg tissue/day)183399
t 1/2(days)2.10.94

In this table, k is the transporter degradation rate constant, r is the transporter production rate, andt1/2 is the half-life of transporter repopulation. These values were calculated by generating a linear fit of the data shown in Fig. 2.