Summary of kinetic parameters of DAT in the striatum of the rat after 10 days of pretreatment with saline or cocaine and a subsequent 10-day withdrawal period
| Saline | Cocaine | |
|---|---|---|
| k (days−1) | 0.33 | 0.74 |
| r (fmol/mg tissue/day) | 183 | 399 |
| t 1/2(days) | 2.1 | 0.94 |
In this table, k is the transporter degradation rate constant, r is the transporter production rate, andt1/2 is the half-life of transporter repopulation. These values were calculated by generating a linear fit of the data shown in Fig. 2.