Table 2

Michaelis-Menten kinetic parameters for the acyl glucuronidation of diclofenac in rat, dog, and human liver microsomes in the presence or absence of the membrane pore-forming peptide alamethicin (at a concentration of 25 μg/mg of microsomal protein)

SpeciesMichaelis-Menten Kinetic Parameters for Acyl Glucuronidation of Diclofenac in Liver Microsomes
Without AlamethicinWith Alamethicin
VmaxKmCLEmbedded Image VmaxKmCLEmbedded Image
pmol/min/mg protein μM μl/min/mg protein pmol/min/mg protein μM μl/min/mg protein