Michaelis-Menten kinetic parameters for the 4′-hydroxylation of diclofenac in rat, dog, and human liver microsomes
Species | Michaelis-Menten Kinetic Parameters for Formation of 4′-Hydroxy Diclofenac in Liver Microsomes | ||
---|---|---|---|
Vmax | Km | CL![]() | |
pmol/min/mg protein | μM | μl/min/mg protein | |
Rat | 1400 | 14 | 100 |
Dog | 440 | 90 | 4.89 |
Human | 1160 | 5.4 | 215 |