Table 1

Summary of in vitro assay results

	CNS	non-CNS
Number of drugs	48	45
Range P _{app A→B}(nm/s)	2.52–748	1.51–792
RangeP _{app B→A} (nm/s)	5.88–788	3.17–834
B → A/A → B P _app range	0.76–44.7	0.78–261
Range passive P _app(nm/s)^1-a	2.17–847	2.49–674
Mean passiveP _app(nm/s)	474^1-b	331^1-b
Number (%) of drugs transported by Pgp	7 (14.6)	19 (42.2)
Number (%) of drugs positive in calcein-AM	28 (58.3)	18 (40.0)

↵1-a Passive permeability was taken as theP _{app B→A} in the presence of GF120918.
↵1-b Significant difference between the mean values for CNS and non-CNS (p < 0.05; Wilcoxon rank sums test).