Effect of dicarboxylate on the uptake of CMPF by the renal cortical slice
| Dicarboxylate | CMPF Uptake | Percentage of Control | |
|---|---|---|---|
| ml/h/g kidney | % | ||
| Control | 3.94 ± 0.36 | 100 ± 9 | (6) |
| α-Ketoglutarate | 0.45 ± 0.16 | 11.5 ± 4.16-a | (6) |
| Glutarate | 1.40 ± 0.25 | 35.6 ± 6.36-a | (6) |
| Succinate | 2.40 ± 0.29 | 61.0 ± 7.36-a | (6) |
| Methylsuccinate | 2.06 ± 0.33 | 52.3 ± 8.56-a | (6) |
| Malonate | 3.80 ± 0.20 | 96.6 ± 5.0 | (3) |
The uptake rates of CMPF into renal cortical slices were measured at 25°C for 1 h. The concentration of CMPF was 20 μM and that of each inhibitor was 1 mM. Each value represents the mean ± S.E. ofn determinations given in parentheses. Each slice was prepared from a different rat.
↵6-a P < 0.01, significantly different from control.