Table 5

Effects of LY341311 on electrocardiographic parameters in conscious dogs with pacing-induced heart failure

BaselineLY341311 (μg/kg/min)
102550100
HR (bpm)115  ± 5106  ± 594  ± 35-150 88  ± 55-150 76  ± 55-150
P-R interval (ms)112  ± 4114  ± 4119  ± 5122  ± 55-150 128  ± 75-150
QRS duration (ms)66  ± 468  ± 470  ± 368  ± 370  ± 3
Q-T interval (ms)222  ± 7230  ± 10243  ± 11249  ± 125-150 270  ± 155-150
Q-Tc interval (ms)306  ± 8303  ± 12302  ± 12299  ± 11298  ± 10

All data are mean ± S.E., n = 9.

  • 5-150P < 0.05 vs. baseline.