Table 4

Effects of LY341311 and dobutamine on coronary blood flow and myocardial O2 consumption in conscious dogs with pacing-induced heart failure

NLY 341311 (100 μg/kg/min)Dobutamine (10 μg/kg/min)
Baseline% ChangeBaseline% Change
Coronary blood flow (ml/min)841  ± 48  ± 64-150 4-151 40  ± 426  ± 54-150
Hematocrit (%)836  ± 2−3  ± 34-151 37  ± 25  ± 24-150
Arterial O2 content (vol %)814.9  ± 0.6−5  ± 24-151 15.4  ± 0.57  ± 24-150
Coronary sinus O2 content (vol %)83.9  ± 0.310  ± 63.8  ± 0.430  ± 104-150
O2 extraction (vol %)811.0  ± 0.7−9  ± 34-150 4-151 11.6  ± 0.6−0.1  ± 2
Myocardial O2 consumption (ml/min)84.3  ± 0.4−2  ± 84-151 4.5  ± 0.429  ± 74-150
Mechanical efficiency (dyne/cm/ml)60.50  ± 0.0672  ± 124-150 4-151 0.56  ± 0.0633  ± 84-150

All data are mean ± S.E.

  • 4-150P < 0.05 vs. baseline

  • 4-151P < 0.05 vs. dobutamine.