Table 2

Effects of LY341311 and dobutamine on hemodynamics and LV function in conscious dogs with pacing-induced heart failure

NLY341311 (100 μg/kg/min)Dobutamine (10 μg/kg/min)
Baseline% ChangeBaseline% Change
Heart rate (bpm)10115  ± 5−32  ± 42-150 2-151 119  ± 54  ± 4
Mean arterial pressure (mm Hg)1082  ± 38  ± 381  ± 31  ± 2
Left atrial pressure (mm Hg)1021  ± 1−3  ± 523  ± 1−7  ± 5
LV end-diastolic diameter (mm)842  ± 10.3  ± 0.242  ± 10.6  ± 0.4
LV systolic pressure (mm Hg)1096  ± 417  ± 32-150 96  ± 29  ± 12-150
LV dP/dtmax (mm Hg/s)101380  ± 6756  ± 62-150 1327  ± 5445  ± 52-150
LV dP/dt/40 (s−1)101218  ± 5144  ± 62-150 1208  ± 5441  ± 62-150
LV fractional shortening (%)810.5  ± 1.163  ± 92-150 10.4  ± 1.043  ± 72-150
LV stroke work (dyne/cm × 103)843  ± 5113  ± 182-150 2-151 41  ± 266  ± 82-150
Minute work (dyne/cm/min × 106)85.2  ± 0.736  ± 112-150 2-151 5.0  ± 0.369  ± 132-150
LV dP/dtmin (mm Hg/s)101593  ± 5831  ± 32-150 1548  ± 6227  ± 32-150
LV relaxation τ (ms)1031  ± 2−19  ± 42-150 2-151 35  ± 2−31  ± 42-150

All data are mean ± S.E.

  • 2-150P < 0.05 vs. baseline;

  • 2-151P < 0.05 vs. dobutamine.