Brain Region | mGluR2/3 | Saline Rats | Cocaine Rats |
---|---|---|---|
Prefrontal cortex | Dimer | 100 ± 22.6 | 166.7 ± 21.31-150 |
Monomer | 100 ± 5.7 | 55.9 ± 9.71-150 | |
Dimer + monomer | 100 ± 12.5 | 125.6 ± 15.9 | |
Pariatal cortex | Dimer | 99.99 ± 9.8 | 96.2 ± 11.3 |
Monomer | N.D. | N.D. | |
Striatum | Dimer | 100 ± 11.1 | 113.7 ± 8.3 |
Monomer | 100 ± 8.9 | 101.0 ± 10.6 | |
Dimer + monomer | 100 ± 9.9 | 110.8 ± 7.9 | |
Accumbens, shell | Dimer | 100 ± 8.2 | 130.9 ± 6.71-150 |
Monomer | 100 ± 12.4 | 85.3 ± 5.9 | |
Dimer + monomer | 100 ± 9.5 | 124.8 ± 5.61-150 | |
Accumbens, core | Dimer | 100 ± 7.3 | 132.8 ± 10.11-150 |
Monomer | 100 ± 6.5 | 103.2 ± 14.5 | |
Dimer +monomer | 100 ± 5.8 | 121.3 ± 7.61-150 | |
VTA | Dimer | 100 ± 14.8 | 126.4 ± 7.9 |
Monomer | 100 ± 13.5 | 108.4 ± 12.3 | |
Dimer +monomer | 100 ± 14.4 | 119.5 ± 6.2 |
Rats were killed at 3 weeks after the last daily cocaine injection. Data are shown as the normalized percentage of change (mean ± S.E.M.) from rats pretreated with daily saline injections.n = 7 for each group and brain area.
N.D., not detected; VTA, ventral tegmental area.
↵1-150 p < 0.05, compared with the saline control group with two-tailed Student's t test.