Table 5

Number of component molecules in VLDL and VLDL diameter of guinea pigs treated with 0.0, 0.8, 3.7, and 13.4 mg/kg/day ASBT inhibitor

TreatmentVLDL Components
FCTGCEPLDiameter (A)
mg/kg/day
ASBT inhibitor
0.0 (control)570 ± 2362161 ± 574239 ± 112414 ± 197327.5 ± 70.9
0.8835 ± 3322273 ± 1297474 ± 325461 ± 355278.8 ± 71.6
3.71005 ± 5022225 ± 1154909 ± 883570 ± 382289.3 ± 58.2
13.4672 ± 2213715 ± 3885-150 387 ± 215703 ± 162433.8 ± 52.95-150

Data are presented as means ± S.D.; n = 10/group. Values in the same column with different superscripts are significantly different as determined by one-way ANOVA and the Newman-Keuls as post hoc test.

  • FC, free cholesterol; CE, cholesteryl ester; PL, phospholipid.

  • 5-150P < 0.05.