Table 3
Mean parameter estimates of keo for groups A through F
| Group | n | keo-nonpar | keo-par | Cmax | keo,app |
|---|---|---|---|---|---|
| min−1 | min−1 | ng · ml−1 | min−1 | ||
| A | 8 | 1.34 ± 0.30 | 1.20 ± 0.31 | 4075 ± 481 | 0.82 ± 0.09 |
| B | 7 | 1.78 ± 0.43 | 1.73 ± 0.40 | 1735 ± 112 | 2.09 ± 0.23 |
| C | 8 | 0.35 ± 0.04 | 0.31 ± 0.03 | 7699 ± 542 | 0.47 ± 0.013-a |
| D | 7 | 0.35 ± 0.08 | 0.35 ± 0.06 | 10678 ± 1452 | 0.41 ± 0.03 |
| E | 7 | 0.33 ± 0.04 | 0.42 ± 0.07 | 16246 ± 1993 | 0.39 ± 0.02 |
| F | 7 | 0.47 ± 0.05 | 0.43 ± 0.06 | 17095 ± 1752 | 0.45 ± 0.04 |
The value of keo was estimated nonparametrically (keo-nonpar), parametrically (keo-par), and parametrically (keo,app) with maximal plasma concentrations (Cmax) as covariate. The concentration-dependent hysteresis was defined as
-
↵3-a Significantly higher than forkeo-par and keo-nonpar (p < 0.05).