Population pharmacokinetic parameter estimates for CL, Q,V1, and V2 with corresponding interindividual coefficient of variation (CV) and 95% confidence interval (CI)
| n | CL | Q | V1 | V2 | |
|---|---|---|---|---|---|
| ml · min−1 · kg−1 | ml · kg−1 | ||||
| Population | 158 ± 29 | 143 ± 31 | 122 ± 20 | 606 ± 48 | |
| CV | 27% | 47% | 49% | 48% | |
| 95% CI | 98–216 | 80–206 | 82–162 | 510–701 | |
| Group | |||||
| A | 8 | 124 ± 12 | 101 ± 19 | 108 ± 18 | 364 ± 462-a |
| B | 7 | 175 ± 8 | 169 ± 12 | 173 ± 10 | 605 ± 63 |
| C | 8 | 181 ± 10 | 185 ± 16 | 131 ± 13 | 674 ± 62 |
| D | 7 | 171 ± 16 | 167 ± 26 | 160 ± 26 | 804 ± 131 |
| E | 7 | 168 ± 17 | 169 ± 19 | 99 ± 6 | 787 ± 84 |
| F | 7 | 154 ± 15 | 135 ± 13 | 98 ± 7 | 775 ± 66 |
Below the population estimates, the averaged individual Bayesian post hoc pharmacokinetic parameter estimates are given for treatment groups A through F (mean ± S.E.M.). The intraindividual residual error was 26.5%.
↵2-a Significantly lower than groups D, E, and F (p < 0.05).