Effect of pregabalin and morphine on colonic threshold in normal rats
| Treatment | Colonic Threshold | S.E.M. | n | p | |
|---|---|---|---|---|---|
| mm Hg | |||||
| Control | 43.33 | ± | 1.23 | 6 | |
| Pregabalin | |||||
| 200 mg/kg s.c. | 46.41 | ± | 2.26 | 8 | N.S. |
| Control | 51.73 | ± | 2.65 | 13 | |
| Morphine | |||||
| 0.01 mg/kg s.c. | 52.92 | ± | 1.86 | 6 | N.S. |
| 0.1 mg/kg s.c. | 60.00 | ± | 4.64 | 5 | N.S. |
| 0.3 mg/kg s.c. | 67.50 | ± | 2.52 | 6 | 1-150 |
| 1 mg/kg s.c. | 71.88 | ± | 1.40 | 6 | 1-150 |
Pregabalin (200 mg/kg s.c.) and morphine (0.01–1 mg/kg s.c.) were administrated 30 min before colonic distension session. Results are expressed as mean of colonic threshold ± S.E.M. (mm Hg) (n = 7–8/per group). Statistical significance between each group (control versus compound) was determined by using a Dunnett's test. Differences were considered statistically significant at p < 0.05.
N.S., not significant versus control.
↵1-150 p < 0.05 versus control.