Table 3

Potency and efficacy of SP in contracting circular muscle from sigmoid colon of normal and disease colon

pEC30AchEmax3-a3-bn
%
Control5.86  ± 0.1965.6  ± 11.426
Ulcerative colitis5.35  ± 0.3461.1  ± 13.012
Diverticular disease4.93  ± 0.35* 42.7  ± 7.811

  • ↵3-a  Relative to 100% response caused by acetylcholine (10 mM).

  • ↵3-b  Response to SP 100 μM; *P < 0.05 compared with control (one-way ANOVA followed by Bonferroni's test).