Table 2

Potency of SP and NKA in contracting circular muscle from different regions of human colon

ColonSPNKA
pD2Emax2-anpD2Emax2-an
% %
Sigmoid5.73  ± 0.0266.3  ± 12.3267.43  ± 0.0860.5  ± 4.1326
Ascending5.33  ± 0.0458.3  ± 7.79117.48  ± 0.0257.5  ± 5.1712
Descending5.54  ± 0.0765.6  ± 4.4067.54  ± 0.2452.4  ± 7.635
  • 2-a  Relative to 100% response caused by acetylcholine (10 mM).