Table 2

Renal clearance analysis of metformin in Oct1(+/+) and (−/−) mice

Recovery (% of dose)CLrenal(0–60)CLtotal
0–20 min20–40 min40–60 min
ml/min/kg
Oct1(+/+)38.3  ± 2.010.9  ± 3.45.73  ± 0.2314.0  ± 3.118.3  ± 1.7
Oct1(−/−)47.4  ± 3.513.8  ± 4.28.94  ± 0.1914.7  ± 2.716.1  ± 1.7

Metformin was intravenously injected at a dose of 5.0 mg/kg. Data are shown as mean ± S.E. (n = 3).