Table 1

Kinetic parameters for the uptake of biguanide compounds in the rOct1-transfected CHO cell line

CompoundsKmVmaxVmax/Km
μM pmol/min/mg protein
Metformin377  ± 381386  ± 1013.68  ± 0.46
Buformin48.8  ± 6.9282  ± 255.78  ± 0.96
Phenformin15.6  ± 1.1150  ± 79.62  ± 0.81

Km and Vmax values were determined by nonlinear regression analysis. Data are shown as mean ± S.E. (n = 3).